Hardest HESI A2 Sections Ranked 2026: Where to Spend Your 40 Hours

The HESI A2 exam is a critical step for aspiring nurses, but not all sections are created equal. Some require significantly more preparation than others, and knowing which areas are the toughest can help you focus your limited study time effectively.

Based on student feedback and expert analysis, we’ve ranked the hardest HESI A2 sections for 2026 and included actionable study strategies to help you succeed. For additional practice, check out our HESI A2 practice test to simulate the real exam experience.

The Hardest HESI A2 Sections Ranked (2026)

Here’s how the HESI A2 sections stack up in terms of difficulty, based on commonly reported challenges:

1. Anatomy & Physiology: Covers 11 body systems in just 25 scored questions, making it the most challenging.
2. Biology: Requires strong foundational knowledge of cellular processes, genetics, and ecology.
3. Math: Focuses on fractions, decimals, ratios, and conversions, with limited calculator use.
4. Chemistry: Tests understanding of chemical reactions, solutions, and basic atomic structure.
5. Reading Comprehension: Demands critical thinking and inference skills.

Section Details & Study Strategies

Let’s break down each of the hardest sections, including their question counts, time limits, and specific study tips.

Section	Questions	Time Limit	Study Tips
Anatomy & Physiology	30 (25 scored)	25 minutes	Focus on body systems & their functions; use flashcards.
Biology	25 (20 scored)	25 minutes	Review cellular respiration, genetics, & ecology.
Math	55 (50 scored)	50 minutes	Memorize conversions & practice word problems.
Chemistry	25 (20 scored)	25 minutes	Study balancing equations & molarity calculations.
Reading	50 (47 scored)	60 minutes	Practice inference & main idea questions.

40-Hour Study Plan

Here’s how to allocate your study time over 40 hours:

• Anatomy & Physiology: 12 hours
• Biology: 8 hours
• Math: 8 hours
• Chemistry: 6 hours
• Reading Comprehension: 4 hours
• Practice Tests: 2 hours

FAQs

1. Which HESI A2 section is the hardest?

Anatomy & Physiology is widely reported as the hardest HESI A2 section due to its comprehensive coverage of 11 body systems in just 25 scored questions.

2. How long does the HESI A2 take?

The exam typically takes 5 to 5.25 hours, depending on the number of sections your nursing program requires.

3. What is the passing score for the HESI A2?

There is no universal passing score; most programs require a minimum of 75% to 80% per section.

4. Can I retake the HESI A2?

Retake policies vary by program, with common waiting periods of 30 to 60 days.

5. How much does the HESI A2 cost?

The exam fee ranges from $40 to $100, depending on the administering institution.

For more exam prep resources, explore our 60-Day Study Plan or ASWB Pass Rates 2026 guide.